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HLA-B*15 subtypes in Burmese population by sequence-based typing.

Authors :
Kongmaroeng C
Romphruk A
Ruangwerayut R
Paupairoj C
Leelayuwat C
Inoko H
Romphruk A
Source :
Tissue antigens [Tissue Antigens] 2009 Aug; Vol. 74 (2), pp. 164-7. Date of Electronic Publication: 2009 Jun 02.
Publication Year :
2009

Abstract

Human leukocyte antigen (HLA)-B*15 encompasses an increasing number of subtypes of more than 150. Frequency studies and a strong genetic association between HLA subtypes and susceptibility to drug hypersensitivity have been reported in different ethnic populations. To identify HLA-B*15 subtypes in Burmese using sequence-based typing (SBT) method, we selected 65 HLA-B*15-positive samples from 170 unrelated healthy Burmese who were genotyped HLA-B* by polymerase chain reaction with the sequence-specific primer method. The frequency of HLA-B*15 in Burmese was found to be 38.2%. By the SBT method, results showed 10 alleles of HLA-B*15 subtypes. Four common alleles, B*1502 (45.2%), B*1532 (16.4%), B*1525 (12.3%), and B*1501 (8.2%), were found in 82.1% of HLA-B*15-positive Burmese. Whereas the B*1501 was the highest in the Caucasians, Koreans, and Japanese, the highest frequency of HLA-B*15 alleles in Burmese was B*1502 (45.2%) that is similar to the frequency found in northeastern Thais and Vietnamese. This study is the first report of HLA-B*15 subtypes in Burmese. These results will provide the basic data in the further study in transplantations, genetic association with diseases, and drug hypersensitivity.

Details

Language :
English
ISSN :
1399-0039
Volume :
74
Issue :
2
Database :
MEDLINE
Journal :
Tissue antigens
Publication Type :
Academic Journal
Accession number :
19497038
Full Text :
https://doi.org/10.1111/j.1399-0039.2009.01281.x