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Treatment of pregabalin toxicity by hemodialysis in a patient with kidney failure.
- Source :
-
American journal of kidney diseases : the official journal of the National Kidney Foundation [Am J Kidney Dis] 2009 Dec; Vol. 54 (6), pp. 1127-30. Date of Electronic Publication: 2009 Jun 03. - Publication Year :
- 2009
-
Abstract
- Pregabalin is prescribed for neuropathic pain. We report the first case of pregabalin toxicity in a hemodialysis patient and her successful treatment with hemodialysis. The patient was a 30-year-old woman on long-term hemodialysis therapy who experienced significant myoclonus of the arms and legs when her dose of pregabalin was mistakenly increased. The drug has 3 properties that contribute to making it amenable to removal by hemodialysis: relatively low molecular weight (159.23 Da), relatively low volume of distribution (0.5 L/kg), and not bound to plasma proteins. We achieved hemodialysis clearance of 88.8 mL/min, which was associated with resolution of symptoms immediately after hemodialysis.
- Subjects :
- Adult
Analgesics blood
Analgesics therapeutic use
Dose-Response Relationship, Drug
Female
Humans
Kidney Failure, Chronic blood
Neuralgia drug therapy
Pregabalin
Time Factors
Treatment Outcome
gamma-Aminobutyric Acid blood
gamma-Aminobutyric Acid poisoning
gamma-Aminobutyric Acid therapeutic use
Analgesics poisoning
Kidney Failure, Chronic therapy
Renal Dialysis
gamma-Aminobutyric Acid analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1523-6838
- Volume :
- 54
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- American journal of kidney diseases : the official journal of the National Kidney Foundation
- Publication Type :
- Academic Journal
- Accession number :
- 19493601
- Full Text :
- https://doi.org/10.1053/j.ajkd.2009.04.014