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Altered fronto-striato-thalamic connectivity in children with Tourette syndrome assessed with diffusion tensor MRI and probabilistic fiber tracking.
- Source :
-
Journal of child neurology [J Child Neurol] 2009 Jun; Vol. 24 (6), pp. 669-78. - Publication Year :
- 2009
-
Abstract
- The aim of the study was to determine whether abnormal connectivity of the fronto-striato-thalamic circuit underlies the morphological changes in subcortical structures of patients with Tourette syndrome and to correlate these changes with neurobehavioral measures. A total of 18 children with Tourette syndrome and 12 age-matched healthy controls underwent diffusion tensor magnetic resonance imaging. Tractography of the fronto-striato-thalamic circuit was achieved using probability distribution function of individual voxels. The Tourette syndrome group had significantly lower probability of connection between caudate nucleus and anterior-dorsolateral-frontal cortex on the left (P = .038). Obsessive-compulsive behavior was negatively associated with connectivity score of the left caudate and anterior dorsolateral frontal cortex (P = .01) and was positively associated with connectivity score for the subcallosal gyrus (P = .009) and for the lentiform nucleus (P = .008). The abnormal connectivity among components of the fronto-striato-thalamic circuit bilaterally (ie, seeds on the caudate and thalamus) in patients with Tourette syndrome provides direct evidence for the involvement of these circuits in the pathophysiology.
- Subjects :
- Adolescent
Brain pathology
Child
Diffusion Magnetic Resonance Imaging
Functional Laterality
Humans
Multivariate Analysis
Neural Pathways pathology
Neuropsychological Tests
Obsessive Behavior complications
Obsessive Behavior pathology
Organ Size
Probability
Tourette Syndrome complications
Caudate Nucleus pathology
Frontal Lobe pathology
Thalamus pathology
Tourette Syndrome pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1708-8283
- Volume :
- 24
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of child neurology
- Publication Type :
- Academic Journal
- Accession number :
- 19491113
- Full Text :
- https://doi.org/10.1177/0883073808327838