Back to Search
Start Over
Human health risk assessment of penicillin/aminopenicillin resistance in enterococci due to penicillin use in food animals.
- Source :
-
Risk analysis : an official publication of the Society for Risk Analysis [Risk Anal] 2009 Jun; Vol. 29 (6), pp. 796-805. - Publication Year :
- 2009
-
Abstract
- Penicillin and ampicillin drugs are approved for use in food animals in the United States to treat, control, and prevent diseases, and penicillin is approved for use to improve growth rates in pigs and poultry. This article considers the possibility that such uses might increase the incidence of ampicillin-resistant Enterococcus faecium (AREF) of animal origin in human infections, leading to increased hospitalization and mortality due to reduced response to ampicillin or penicillin. We assess the risks from continued use of penicillin-based drugs in food animals in the United States, using several assumptions to overcome current scientific uncertainties and data gaps. Multiplying the total at-risk population of intensive care unit (ICU) patients by a series of estimated factors suggests that not more than 0.04 excess mortalities per year (under conservative assumptions) to 0.14 excess mortalities per year (under very conservative assumptions) might be prevented in the whole U.S. population if current use of penicillin drugs in food animals were discontinued and if this successfully reduced the prevalence of AREF infections among ICU patients. These calculations suggest that current penicillin usage in food animals in the United States presents very low (possibly zero) human health risks.
- Subjects :
- Animals
Anti-Bacterial Agents adverse effects
Drug Resistance, Microbial
Gram-Positive Bacterial Infections microbiology
Gram-Positive Bacterial Infections mortality
Humans
Intensive Care Units
Penicillanic Acid adverse effects
Penicillanic Acid pharmacology
Penicillins adverse effects
Risk Assessment
Animals, Domestic
Anti-Bacterial Agents pharmacology
Enterococcus faecium drug effects
Penicillanic Acid analogs & derivatives
Penicillins pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1539-6924
- Volume :
- 29
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Risk analysis : an official publication of the Society for Risk Analysis
- Publication Type :
- Academic Journal
- Accession number :
- 19490520
- Full Text :
- https://doi.org/10.1111/j.1539-6924.2009.01202.x