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Rapid clearance of the circulating metastatic factor autotaxin by the scavenger receptors of liver sinusoidal endothelial cells.
- Source :
-
Cancer letters [Cancer Lett] 2009 Nov 01; Vol. 284 (2), pp. 216-21. Date of Electronic Publication: 2009 May 30. - Publication Year :
- 2009
-
Abstract
- Autotaxin, also known as NPP2 (nucleotide pyrophosphatase/phosphodiesterase 2), is a secreted lysophospholipase-D that generates lysophosphatidic acid and thereby promotes the metastatic and invasive properties of tumor cell as well as angiogenesis. We show here that, in mice, NPP2 is cleared from the circulation within minutes and is retained by the liver sinusoidal endothelial cells (LSECs). The binding of NPP2 to isolated LSECs resulted in its degradation and could be competed for with ligands of the scavenger receptor family. Our finding that circulating NPP2 has a rapid turnover has important implications for its development as an anti-cancer target.<br /> (2009 Elsevier Ireland Ltd.)
- Subjects :
- Animals
Cells, Cultured metabolism
Formaldehyde pharmacology
Humans
Injections, Intravenous
Male
Metabolic Clearance Rate
Mice
Multienzyme Complexes administration & dosage
Multienzyme Complexes blood
Neoplasm Metastasis prevention & control
Neoplasm Proteins administration & dosage
Neoplasm Proteins blood
Neoplasm Proteins physiology
Phosphodiesterase I administration & dosage
Phosphodiesterase I blood
Phosphoric Diester Hydrolases administration & dosage
Phosphoric Diester Hydrolases blood
Pyrophosphatases administration & dosage
Pyrophosphatases blood
Rats
Rats, Wistar
Receptors, Scavenger antagonists & inhibitors
Serum Albumin, Bovine pharmacology
Endothelial Cells metabolism
Liver blood supply
Multienzyme Complexes pharmacokinetics
Neoplasm Metastasis physiopathology
Neoplasm Proteins pharmacokinetics
Phosphodiesterase I pharmacokinetics
Phosphoric Diester Hydrolases pharmacokinetics
Pyrophosphatases pharmacokinetics
Receptors, Scavenger metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7980
- Volume :
- 284
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cancer letters
- Publication Type :
- Academic Journal
- Accession number :
- 19482419
- Full Text :
- https://doi.org/10.1016/j.canlet.2009.04.029