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Synthesis and antimicrobial activity of 4-hydroxy-4-(pyridyl)alk-3-en-2-ones.
- Source :
-
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2009 Jul 01; Vol. 17 (13), pp. 4323-6. Date of Electronic Publication: 2009 May 15. - Publication Year :
- 2009
-
Abstract
- 4-Hydroxy-4-(pyridyl)alk-3-en-2-ones were prepared by base-mediated condensation of ketones with pyridinecarboxylates. Several derivatives show weak antimicrobial activity against Gram-positive and Gram-negative bacteria.
- Subjects :
- Bacillus subtilis growth & development
Escherichia coli growth & development
Ketones chemical synthesis
Ketones chemistry
Pyridines chemistry
Staphylococcus aureus growth & development
Anti-Bacterial Agents chemical synthesis
Anti-Bacterial Agents pharmacology
Bacillus subtilis drug effects
Escherichia coli drug effects
Ketones pharmacology
Pyridines chemical synthesis
Pyridines pharmacology
Staphylococcus aureus drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3391
- Volume :
- 17
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 19481948
- Full Text :
- https://doi.org/10.1016/j.bmc.2009.05.023