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Runx and ThPOK: a balancing act to regulate thymocyte lineage commitment.

Authors :
Egawa T
Source :
Journal of cellular biochemistry [J Cell Biochem] 2009 Aug 15; Vol. 107 (6), pp. 1037-45.
Publication Year :
2009

Abstract

CD4-positive helper T cells and CD8-positive cytotoxic T cells comprise the majority of T lymphocytes present in secondary lymphoid organs and are essential for acquired immunity. These two populations are derived from common precursors in the thymus and selected through interaction between their clonal T-cell receptors and major histocompatibility complex molecules. Although intensely studied as a model system for binary cell fate decisions, the mechanisms underlying the helper versus cytotoxic lineage choice in the thymus has been elusive. In the past few years, it has been demonstrated that the Runx family of transcription factors, particularly Runx3, is essential for the generation of cytotoxic lineage T cells, whereas the ThPOK zinc finger transcription factor that plays a crucial role in the differentiation of the helper lineage. Recent works have implied that a cross-regulation between Runx and ThPOK contributes to appropriate thymocyte lineage commitment. In this article, recent findings on the transcription factor networks governing thymocyte lineage decisions are discussed, focusing on the two factors, and provide insights into mechanisms of lineage-specific gene regulation in the process of T-cell commitments.<br /> ((c) 2009 Wiley-Liss, Inc.)

Details

Language :
English
ISSN :
1097-4644
Volume :
107
Issue :
6
Database :
MEDLINE
Journal :
Journal of cellular biochemistry
Publication Type :
Academic Journal
Accession number :
19479890
Full Text :
https://doi.org/10.1002/jcb.22212