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Mapping of brain acetylcholinesterase alterations in Lewy body disease by PET.
- Source :
-
Neurology [Neurology] 2009 Jul 28; Vol. 73 (4), pp. 273-8. Date of Electronic Publication: 2009 May 27. - Publication Year :
- 2009
-
Abstract
- Objective: To characterize brain cholinergic deficits in Parkinson disease (PD), PD with dementia (PDD), and dementia with Lewy bodies (DLB).<br />Methods: Participants included 18 patients with PD, 21 patients with PDD/DLB, and 26 healthy controls. The PD group consisted of nine patients with early PD, each with a disease duration of less than 3 years, five of whom were de novo PD patients, and nine patients with advanced PD, each with a disease duration greater than or equal to 3 years. The PDD/DLB group consisted of 10 patients with PDD and 11 patients with DLB. All subjects underwent PET scans with N-[11C]-methyl-4-piperidyl acetate to measure brain acetylcholinesterase (AChE) activity. Brain AChE activity levels were estimated voxel-by-voxel in a three-compartment analysis using the arterial input function, and compared among our subject groups through both voxel-based analysis using the statistical parametric mapping software SPM5 and volume-of-interest analysis.<br />Results: Among patients with PD, AChE activity was significantly decreased in the cerebral cortex and especially in the medial occipital cortex (% reduction compared with the normal mean = -12%) (false discovery rate-corrected p value <0.01). Patients with PDD/DLB, however, had even lower AChE activity in the cerebral cortex (% reduction = -27%) (p < 0.01). There was no significant difference between early PD and advanced PD groups or between DLB and PDD groups in the amount by which regional AChE activity in the brain was reduced.<br />Conclusions: Brain cholinergic dysfunction occurs in the cerebral cortex, especially in the medial occipital cortex. It begins in early Parkinson disease, and is more widespread and profound in both Parkinson disease with dementia and dementia with Lewy bodies.
- Subjects :
- Acetylcholinesterase analysis
Aged
Basal Nucleus of Meynert diagnostic imaging
Basal Nucleus of Meynert pathology
Biomarkers analysis
Biomarkers metabolism
Brain Mapping
Cerebral Cortex diagnostic imaging
Cerebral Cortex metabolism
Cerebral Cortex pathology
Cerebral Cortex physiopathology
Cholinergic Fibers pathology
Cohort Studies
Diagnosis, Differential
Disease Progression
Down-Regulation physiology
Humans
Immunohistochemistry
Lewy Body Disease diagnostic imaging
Lewy Body Disease pathology
Middle Aged
Neural Pathways diagnostic imaging
Neural Pathways metabolism
Neural Pathways pathology
Neural Pathways physiopathology
Occipital Lobe diagnostic imaging
Occipital Lobe metabolism
Occipital Lobe pathology
Occipital Lobe physiopathology
Parkinson Disease diagnostic imaging
Parkinson Disease pathology
Radionuclide Imaging
Acetylcholine deficiency
Acetylcholinesterase metabolism
Basal Nucleus of Meynert enzymology
Cholinergic Fibers enzymology
Lewy Body Disease enzymology
Parkinson Disease enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 1526-632X
- Volume :
- 73
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 19474411
- Full Text :
- https://doi.org/10.1212/WNL.0b013e3181ab2b58