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Bis-neonicotinoid insecticides: Observed and predicted binding interactions with the nicotinic receptor.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 Jul 01; Vol. 19 (13), pp. 3449-52. Date of Electronic Publication: 2009 May 09. - Publication Year :
- 2009
-
Abstract
- The bis-pharmacophore approach applied to neonicotinoid insecticides reveals high binding affinity for heptamethylene bis-N(3),N(3')-imidacloprid fitting a nicotinic acetylcholine receptor model wherein the chloropyridine moieties contact loops E and F and the alkylene linker bridges these two distant domains.
- Subjects :
- Animals
Binding Sites
Computer Simulation
Drosophila
Imidazoles chemical synthesis
Insecticides chemical synthesis
Neonicotinoids
Nicotinic Antagonists chemical synthesis
Nitro Compounds chemical synthesis
Protein Binding
Receptors, Nicotinic metabolism
Imidazoles chemistry
Insecticides chemistry
Nicotinic Antagonists chemistry
Nitro Compounds chemistry
Receptors, Nicotinic chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 19
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 19473841
- Full Text :
- https://doi.org/10.1016/j.bmcl.2009.05.016