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Effect of overweight/obesity on recovery after post-infectious glomerulonephritis.
- Source :
-
Clinical nephrology [Clin Nephrol] 2009 Jun; Vol. 71 (6), pp. 632-6. - Publication Year :
- 2009
-
Abstract
- Background: Children with post-infectious glomerulonephritis (PIGN) rapidly recover and have excellent long-term outcomes. After encountering several overweight/obese children with persistent urinary abnormalities during recovery from PIGN, we conducted this retrospective study to determine if overweight/obese status prolonged time to resolution of renal abnormalities after PIGN.<br />Methods: Records of 20 children with PSGN evaluated between 1/98 and 12/05 were abstracted for demographics, clinical and laboratory data. Primary outcome measures were time to resolution of hypertension, proteinuria, microhematuria, and low complement C3. The effect of overweight/obese status on outcomes was determined using Kaplan Meier Survival and the log-rank test.<br />Results: The median age was 8 years; 30% were overweight/obese. At presentation, 17 (85%) were hypertensive, 10 (50%) had impaired glomerular filtration (GFR), and 18 (90%) had proteinuria. At last follow-up (median 2.8 months) 12% had hypertension, 55% had microhematuria, 5% had proteinuria but none had low GFR. Median time to normalize was: 30 days (GFR), 45 days (blood pressure), 6 weeks (C3) and 6 months (microhematuria). Log rank test showed that proteinuria-, hypertension-, and hematuria-free survival were all lower in children who were overweight/obese although none of the differences were statistically significant. Time to normalization of C3 was shorter in obese/ overweight children.<br />Conclusion: In conclusion, overweight/obese children appear to have greater residual renal injury after PIGN. The earlier C3 normalization in overweight/ obese children may indicate that the adverse effect of weight on recovery is from hemodynamic rather than inflammatory factors. Close follow-up of overweight/obese children who develop PIGN is warranted to ensure optimal long-term outcomes.
- Subjects :
- Adolescent
Body Mass Index
Child
Child, Preschool
Cross-Sectional Studies
Female
Follow-Up Studies
Glomerular Filtration Rate
Glomerulonephritis diagnosis
Hematuria complications
Hematuria diagnosis
Humans
Hypertension diagnosis
Infections diagnosis
Male
Obesity diagnosis
Prognosis
Proteinuria diagnosis
Retrospective Studies
Glomerulonephritis complications
Hypertension complications
Infections complications
Obesity complications
Proteinuria complications
Recovery of Function
Subjects
Details
- Language :
- English
- ISSN :
- 0301-0430
- Volume :
- 71
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Clinical nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 19473631
- Full Text :
- https://doi.org/10.5414/cnp71632