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Mutation L437P in the 2B domain of keratin 1 causes diffuse palmoplantar keratoderma in a Chinese pedigree.
- Source :
-
Journal of the European Academy of Dermatology and Venereology : JEADV [J Eur Acad Dermatol Venereol] 2009 Sep; Vol. 23 (9), pp. 1079-82. Date of Electronic Publication: 2009 Mar 17. - Publication Year :
- 2009
-
Abstract
- Diffuse palmoplantar keratoderma (DPPK) is an autosomal dominant genodermatosis characterized by uniform hyperkeratosis of the palm and sole epidermis. This disorder can be caused by mutations in the genes keratin 1, keratin 9, keratin 16, desmoglein 1 and plakoglobin. Here we present a DPPK Chinese pedigree and identify the aetiology as a novel missense mutation, L437P, located in a highly conserved helix motif in domain 2B of KRT1. Functional analysis shows that overexpression of the L437P mutant in cultured cells leads to abnormal intermediate filament networks and filament aggregation. This gain-of-function mutation highlights the role of domain 2B in mediating filament assembly.
- Subjects :
- China
Female
Genetic Predisposition to Disease ethnology
Genetic Predisposition to Disease genetics
Genotype
Humans
Intermediate Filaments pathology
Keratoderma, Palmoplantar, Diffuse pathology
Male
Phenotype
Keratin-1 genetics
Keratoderma, Palmoplantar, Diffuse ethnology
Keratoderma, Palmoplantar, Diffuse genetics
Mutation, Missense genetics
Pedigree
Subjects
Details
- Language :
- English
- ISSN :
- 1468-3083
- Volume :
- 23
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of the European Academy of Dermatology and Venereology : JEADV
- Publication Type :
- Academic Journal
- Accession number :
- 19470048
- Full Text :
- https://doi.org/10.1111/j.1468-3083.2009.03175.x