Common polymorphisms in the interleukin-22 gene are not associated with chronic plaque psoriasis.

Authors :: Weger W
Hofer A
Wolf P
El-Shabrawi Y
Renner W
Kerl H
Salmhofer W
Source :: Experimental dermatology [Exp Dermatol] 2009 Sep; Vol. 18 (9), pp. 796-8. Date of Electronic Publication: 2009 Mar 27.
Publication Year :: 2009
Abstract: Background: Psoriasis is a chronic inflammatory skin disease. Among other cytokines, interleukin 22 (IL-22) has been implicated in the pathogenesis of chronic plaque psoriasis. The purpose of this study was to investigate a hypothesized association between common IL-22 gene polymorphisms and chronic plaque psoriasis.<br />Methods: Genotypes of 10 common polymorphisms of the IL-22 gene were determined by fluorogenic 5' exonuclease assays (TaqMan) in 475 patients with chronic plaque psoriasis and 252 controls.<br />Results: Two blocks of high linkage disequilibrium, formed by eight polymorphisms upstream of exon 5 (rs2227485, rs2227491, rs2046068, rs1179251, rs1012356, rs2227501, rs2227503, rs976748) and two polymorphisms in the 3' near gene region (rs1182844, rs1179246), were observed within the IL-22 gene. Neither single polymorphisms nor haplotypes were significantly associated with the presence or clinical features of chronic plaque psoriasis (P > 0.05).<br />Conclusions: Our data suggest that the investigated IL-22 gene polymorphisms are unlikely major risk factors for chronic plaque psoriasis.

Subjects :: Adult
Case-Control Studies
Female
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Young Adult
Interleukin-22
Interleukins genetics
Psoriasis genetics

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