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Clinicopathological analyses of triple negative breast cancer using surveillance data from the Registration Committee of the Japanese Breast Cancer Society.
- Source :
-
Breast cancer (Tokyo, Japan) [Breast Cancer] 2010 Apr; Vol. 17 (2), pp. 118-24. Date of Electronic Publication: 2009 May 23. - Publication Year :
- 2010
-
Abstract
- Background: Triple negative (TN) breast cancer is defined as a subtype that is negative for estrogen receptor (ER), progesterone receptor (PgR), and human epidermal growth factor receptor 2 (HER2). To clarify the characteristics of TN breast cancer, surveillance data of the Registration Committee of the Japanese Breast Cancer Society were analyzed.<br />Method: Of 14,748 cases registered in 2004, 11,705 (79.4%) were examined for ER, PgR, and HER2. Of these, the most prevalent (53.8%) was a hormone-responsive subtype with ER positive/PgR positive/HER2 negative, followed by TN subtype (15.5%).<br />Results: The proportion of postmenopausal patients was relatively high in the TN subtype. This cancer was diagnosed at a slightly advanced stage and with more cases positive for lymph node metastases than other subtypes. Morphologically, the TN subtype was more frequently classified as solid-tubular carcinoma. Mucinous, tubular, or secretary carcinomas were frequently found in the hormone receptor positive/HER2 negative subtype, while squamous cell carcinoma, spindle cell carcinoma, and metaplastic carcinoma with bone/cartilage metaplasia were very frequently found in the TN group. Apocrine carcinoma was also found very frequently in the TN group. Selection of chemotherapy was not based on receptor subtypes, but was determined by the degree of tumor progression.<br />Conclusions: Although TN types are similar to basal-like breast tumor, as determined by gene profiling, their diagnosis needs verification by determination of the level of epidermal growth factor receptor or cytokeratin 5/6 expression. TN type should be examined further for immunohistochemical features and analyzed for prognostic details in this cohort.
- Subjects :
- Adenocarcinoma metabolism
Adenocarcinoma pathology
Adenocarcinoma, Scirrhous metabolism
Adenocarcinoma, Scirrhous pathology
Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Biomarkers, Tumor metabolism
Breast Neoplasms metabolism
Carcinoma metabolism
Carcinoma pathology
Carcinoma, Intraductal, Noninfiltrating metabolism
Carcinoma, Intraductal, Noninfiltrating pathology
Carcinoma, Lobular metabolism
Carcinoma, Lobular pathology
Female
Humans
Japan
Middle Aged
Prognosis
Receptor, ErbB-2 metabolism
Registries
Societies, Medical statistics & numerical data
Young Adult
Breast Neoplasms pathology
ErbB Receptors metabolism
Receptors, Estrogen metabolism
Receptors, Progesterone metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1880-4233
- Volume :
- 17
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Breast cancer (Tokyo, Japan)
- Publication Type :
- Academic Journal
- Accession number :
- 19466512
- Full Text :
- https://doi.org/10.1007/s12282-009-0113-0