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Association of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma2 with decreased basic metabolic rate in women with polycystic ovary syndrome.
- Source :
-
European journal of endocrinology [Eur J Endocrinol] 2009 Aug; Vol. 161 (2), pp. 317-22. Date of Electronic Publication: 2009 May 22. - Publication Year :
- 2009
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Abstract
- Objective: The peroxisome proliferator-activated receptor (PPAR)gamma is a transcription factor involved in glucose homeostasis and energy metabolism. A missense mutation at codon 12 in the PPARgamma2 has been associated with increased body mass index (BMI) and attenuated insulin resistance (IR) in polycystic ovary syndrome (PCOS). We have recently shown a decreased basic metabolic rate (BMR) in PCOS. The aim of the present study is to determine the prevalence of the Pro12Ala polymorphism of the PPARgamma2 gene and its associations with indices of IR and BMR in lean and slightly overweight PCOS women.<br />Design: Case-control association study involving 156 PCOS women with biochemical hyperandrogenism, chronic anovulation and polycystic ovarian morphology in ultrasound and 56 unrelated healthy controls.<br />Methods: Hormonal determinations were performed by electrochemiluminescence quantitation or RIA. BMR was measured by indirect calorimetry. All subjects were genotyped by a PCR-restriction fragment length polymorphism assay.<br />Results: Genotype frequencies of the Pro12Ala polymorphism in PPARgamma2 did not differ among PCOS women and control subjects. The presence of Pro12Ala polymorphism of PPARgamma2 was associated with lower BMR (P=0.04). This finding was valid in our subgroup of lean PCOS (BMI<25 kg/m(2)), in which the Ala variant was also associated with higher total testosterone values.<br />Conclusion: The Pro12Ala polymorphism in the PPARgamma2 gene is associated with decreased BMR in women with PCOS and biochemical hyperandrogenemia. These young women are therefore at risk to increase their body weight and should restrict their energy intake by diet and enhance their energy expenditure by exercise.
- Subjects :
- Adult
Basal Metabolism genetics
Blood Glucose metabolism
Calorimetry, Indirect
Case-Control Studies
DNA chemistry
DNA genetics
Female
Genetic Variation
Genotype
Humans
Insulin blood
Insulin Resistance physiology
Mutation, Missense
Polycystic Ovary Syndrome blood
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Statistics, Nonparametric
Testosterone blood
Young Adult
PPAR gamma genetics
Polycystic Ovary Syndrome genetics
Polycystic Ovary Syndrome metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1479-683X
- Volume :
- 161
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- European journal of endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 19465486
- Full Text :
- https://doi.org/10.1530/EJE-08-1014