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[Diagnostics of genital herpesvirus infection in women with tubal-peritoneal infertility].
- Source :
-
Zhurnal mikrobiologii, epidemiologii i immunobiologii [Zh Mikrobiol Epidemiol Immunobiol] 2009 Mar-Apr (2), pp. 80-5. - Publication Year :
- 2009
-
Abstract
- Aim: Optimization of diagnostics of genital herpesvirus infection (herpes simplex virus types 1 and 2, cytomegalovirus [CMV]) in women with tubal-peritoneal infertility on the basis of detection of viral material in various parts of genital system using polymerase chain reaction (PCR) and revealing pathogenetically significant systemic abnormalitites of cytokine- and nitroxidergic regulation.<br />Materials and Methods: Sixty-three women with tubal-peritoneal infertility were included in the study. Immunoenzyme assay, PCR, and modified Griess method were used.<br />Results: In cervical canal herpesvirus infection was detected together with other agents in 30.1% of cases. In upper parts of reproductive system monoinfection with herpesvirus was detected in 74.63% of cases (herpes virus types 1 and 2--in 46.03%, CMV--in 28.6% of women). Increased levels of stable end metabolites of nitric oxide and cytokines were noted in sera of tested women.<br />Conclusion: Inflammatory changes in reproductive organs in women with tubal-peritoneal infertility are determined by chronic herpesvirus infection. This leads to Th1 polarization of immune response and developing of immune-mediated inflammation.
- Subjects :
- Adult
Cervix Uteri virology
Chronic Disease
Cytokines blood
Cytomegalovirus genetics
Cytomegalovirus isolation & purification
Cytomegalovirus Infections complications
Cytomegalovirus Infections diagnosis
Fallopian Tubes virology
Female
Herpes Genitalis complications
Herpes Genitalis virology
Herpesvirus 1, Human genetics
Herpesvirus 2, Human genetics
Humans
Infertility, Female blood
Nitric Oxide blood
Nitric Oxide metabolism
DNA, Viral analysis
Herpes Genitalis diagnosis
Herpesvirus 1, Human isolation & purification
Herpesvirus 2, Human isolation & purification
Infertility, Female virology
Subjects
Details
- Language :
- Russian
- ISSN :
- 0372-9311
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Zhurnal mikrobiologii, epidemiologii i immunobiologii
- Publication Type :
- Academic Journal
- Accession number :
- 19459485