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[Effect of volatile oil from nutmeg on liver microsomal cytochrome P450 in mice].
- Source :
-
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2009 Feb; Vol. 34 (4), pp. 447-9. - Publication Year :
- 2009
-
Abstract
- Objective: To study the effect of the volatile oil from nutmeg on liver microsomal cytochrome P450 in mice.<br />Method: Mice were administered the volatile oil from nutmeg at 0.4, 0.8 and 1.2 mg x g(-1), respectively, twice a day for 10 days. And then, the contents of liver microsomal cytochrome P450 (CYP), cytochrome b5 (Cytb5), MDA and GST in serum were examined by UV chromatography method.<br />Result: The contents of liver CYP, Cytb5 and GST in serum were increased significantly (P < 0.01) and the contents of MDA was reduced significantly (P < 0.01).<br />Conclusion: The volatile oil from nutmeg showed induction effect on the hepatic microsomal CYP in mice.
- Subjects :
- Animals
Cytochromes b5 metabolism
Drugs, Chinese Herbal pharmacology
Female
Gene Expression Regulation, Enzymologic
Male
Mice
Microsomes, Liver enzymology
Plant Oils pharmacology
Cytochrome P-450 Enzyme System metabolism
Microsomes, Liver drug effects
Myristica chemistry
Oils, Volatile pharmacology
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1001-5302
- Volume :
- 34
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
- Publication Type :
- Academic Journal
- Accession number :
- 19459309