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Transcriptional variation of regulatory and virulence genes due to different media in Staphylococcus aureus.

Transcriptional variation of regulatory and virulence genes due to different media in Staphylococcus aureus.

Authors :
Ray B
Ballal A
Manna AC
Source :
Microbial pathogenesis [Microb Pathog] 2009 Aug; Vol. 47 (2), pp. 94-100. Date of Electronic Publication: 2009 May 18.
Publication Year :
2009

Abstract

The pathogenesis of staphylococcal infections is a multifactorial process that depends on expression of different virulence factors. Expression of these factors is controlled by multiple regulatory systems in conjunction with environmental signals. Most of the genetic studies in Staphylococcus aureus have been performed using different growth media, therefore, we examined the effects of different growth media on transcription of the selective target (e.g., hla, hlb, spa, sspA) and regulatory (e.g., agr, sarA family) genes. The results from this study suggest that different growth media have substantial effect on transcription of various genes being analyzed. Interestingly, when compared with the wild-type, the isogenic sarA mutant showed a media-dependent distinct regulatory effect on expression of the target genes.

Details

Language :
English
ISSN :
1096-1208
Volume :
47
Issue :
2
Database :
MEDLINE
Journal :
Microbial pathogenesis
Publication Type :
Academic Journal
Accession number :
19450677
Full Text :
https://doi.org/10.1016/j.micpath.2009.05.001