Back to Search
Start Over
Transcriptional variation of regulatory and virulence genes due to different media in Staphylococcus aureus.
Transcriptional variation of regulatory and virulence genes due to different media in Staphylococcus aureus.
- Source :
-
Microbial pathogenesis [Microb Pathog] 2009 Aug; Vol. 47 (2), pp. 94-100. Date of Electronic Publication: 2009 May 18. - Publication Year :
- 2009
-
Abstract
- The pathogenesis of staphylococcal infections is a multifactorial process that depends on expression of different virulence factors. Expression of these factors is controlled by multiple regulatory systems in conjunction with environmental signals. Most of the genetic studies in Staphylococcus aureus have been performed using different growth media, therefore, we examined the effects of different growth media on transcription of the selective target (e.g., hla, hlb, spa, sspA) and regulatory (e.g., agr, sarA family) genes. The results from this study suggest that different growth media have substantial effect on transcription of various genes being analyzed. Interestingly, when compared with the wild-type, the isogenic sarA mutant showed a media-dependent distinct regulatory effect on expression of the target genes.
- Subjects :
- Bacterial Proteins metabolism
Culture Media metabolism
Gene Expression Regulation, Bacterial
Staphylococcus aureus chemistry
Staphylococcus aureus metabolism
Virulence Factors metabolism
Bacterial Proteins genetics
Culture Media chemistry
Staphylococcus aureus genetics
Transcription, Genetic
Virulence Factors genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1096-1208
- Volume :
- 47
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Microbial pathogenesis
- Publication Type :
- Academic Journal
- Accession number :
- 19450677
- Full Text :
- https://doi.org/10.1016/j.micpath.2009.05.001