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Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche.
- Source :
-
Nature genetics [Nat Genet] 2009 Jun; Vol. 41 (6), pp. 734-8. Date of Electronic Publication: 2009 May 17. - Publication Year :
- 2009
-
Abstract
- Earlier menarche correlates with shorter adult height and higher childhood body fat. We conducted a genome-wide association study of age at menarche (AAM) on 15,297 Icelandic women. Combined analysis with replication sets from Iceland, Denmark and the Netherlands (N = 10,040) yielded a significant association between rs314280[T] on 6q21, near the LIN28B gene, and AAM (effect = 1.2 months later per allele; P = 1.8 × 10(-14)). A second SNP within the same linkage disequilibrium (LD) block, rs314277, splits rs314280[T] into two haplotypes with different effects (0.9 months and 1.9 months per allele). These variants have been associated with greater adult height. The association with adult height did not account for the association with AAM or vice versa. Other variants, previously associated with height, did not associate significantly with AAM. Given the link between body fat and AAM, we also assessed 11 variants recently associated with higher body mass index (BMI) and 5 of those associated with earlier AAM.
- Subjects :
- Adipose Tissue anatomy & histology
Adult
Anthropometry methods
Base Sequence
Body Height genetics
Body Mass Index
Chromosome Mapping
Denmark
Female
Humans
Iceland
Netherlands
Transcription, Genetic
Aging physiology
Chromosomes, Human, Pair 6 genetics
Genetic Variation
Genome-Wide Association Study
Menarche genetics
Polymorphism, Single Nucleotide genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1546-1718
- Volume :
- 41
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Nature genetics
- Publication Type :
- Academic Journal
- Accession number :
- 19448622
- Full Text :
- https://doi.org/10.1038/ng.383