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Sequoia regulates cell fate decisions in the external sensory organs of adult Drosophila.
- Source :
-
EMBO reports [EMBO Rep] 2009 Jun; Vol. 10 (6), pp. 636-41. Date of Electronic Publication: 2009 May 15. - Publication Year :
- 2009
-
Abstract
- The adult Drosophila external sensory organ (ESO), comprising the hair, socket, neuron, sheath and glia cells, arises through the asymmetric division of sensory organ precursor cells (SOPs). In a mosaic screen designed to identify new components in ESO development, we isolated mutations in sequoia, which encodes a putative zinc-finger transcription factor that has previously been shown to have a role in dendritogenesis. Here, we show that adult clones mutant for seq exhibit a loss of hair cells and a gain of socket cells. We propose that the seq mutant phenotype arises, in part, owing to the loss of several crucial transcription factors known to be important in peripheral nervous system development such as D-Pax2, Prospero and Hamlet. Thus, Sequoia is a new upstream regulator of genes that orchestrates cell fate specification during development of the adult ESO lineage.
- Subjects :
- Animals
Mutation genetics
Phenotype
Receptors, Notch metabolism
Signal Transduction
Cell Lineage
DNA-Binding Proteins metabolism
Drosophila Proteins metabolism
Drosophila melanogaster cytology
Drosophila melanogaster metabolism
Nerve Tissue Proteins metabolism
Sense Organs cytology
Sense Organs metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1469-3178
- Volume :
- 10
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- EMBO reports
- Publication Type :
- Academic Journal
- Accession number :
- 19444309
- Full Text :
- https://doi.org/10.1038/embor.2009.66