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Rapid quantitative procalcitonin measurement to diagnose nosocomial infections in newborn infants.
- Source :
-
Archives of disease in childhood. Fetal and neonatal edition [Arch Dis Child Fetal Neonatal Ed] 2009 Sep; Vol. 94 (5), pp. F345-8. Date of Electronic Publication: 2009 May 12. - Publication Year :
- 2009
-
Abstract
- Background and Objective: Serum procalcitonin (PCT) monitoring may help clinicians to manage nosocomial infections in neonates. This study investigated the diagnostic value of a new, rapid method to measure PCT and sought to determine the best cut-off value.<br />Methods: This monocentric, prospective study included all newborn infants with clinical suspicion of infection in a neonatal intensive care unit. Rapid, automated PCT measurements were performed on blood samples obtained for C-reactive protein (CRP) measurement. Negative and positive predictive values, sensitivity and specificity were calculated. Logistic regression analysis determined the best cut-off value to obtain a negative predictive value of PCT that was at least 15% above that of CRP.<br />Results: Between June 2005 and May 2006, 73 newborn infants with a median (Q25-Q75) gestational age of 28 (26-30) weeks and a birth weight of 995 (720-1350) g were included. Thirty (41%) were infected. The best PCT cut-off value was 0.6 ng/ml, which provided a negative predictive value of 100%. The sensitivity, specificity and positive predictive value were 100%, 65%, and 67%, respectively, for PCT at the 0.6 ng/ml cut-off value.<br />Conclusion: Rapid measurement of PCT could help to rule out nosocomial infection in newborn infants hospitalised in intensive care units.
- Subjects :
- Biomarkers blood
Calcitonin Gene-Related Peptide
Cross Infection blood
Cross Infection prevention & control
Early Diagnosis
Female
Humans
Infant, Newborn
Intensive Care, Neonatal
Male
Predictive Value of Tests
Prospective Studies
Calcitonin blood
Cross Infection diagnosis
Protein Precursors blood
Subjects
Details
- Language :
- English
- ISSN :
- 1468-2052
- Volume :
- 94
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Archives of disease in childhood. Fetal and neonatal edition
- Publication Type :
- Academic Journal
- Accession number :
- 19439432
- Full Text :
- https://doi.org/10.1136/adc.2008.155754