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A cost-benefit analysis of preimplantation genetic diagnosis for carrier couples of cystic fibrosis.
- Source :
-
Fertility and sterility [Fertil Steril] 2010 Apr; Vol. 93 (6), pp. 1793-804. Date of Electronic Publication: 2009 May 12. - Publication Year :
- 2010
-
Abstract
- Objective: To perform a cost-benefit analysis of preimplantation genetic diagnosis (PGD) for carrier couples of cystic fibrosis (CF) compared with the alternative of natural conception (NC) followed by prenatal testing and termination of affected pregnancies.<br />Design: Cost-benefit analysis using a decision analytic model.<br />Setting: Outpatient reproductive health practices.<br />Patient(s): A simulated cohort of 1,000 female patients.<br />Intervention(s): We calculated the net benefit of giving birth to a child as the present value of lifetime earnings minus lifetime medical costs.<br />Main Outcome Measure(s): Net benefits in dollars.<br />Result(s): When used for women younger than 35 years of age, the net benefit of PGD over NC was $182,000 ($715,000 vs. $532,000, respectively). For women aged 35-40 years, the net benefit of PGD over NC was $114,000 ($634,000 vs. $520,000, respectively). For women older than 40 years, however, the net benefit of PGD over NC was -$148,000 ($302,000 vs. $450,000, respectively).<br />Conclusion(s): Preimplantation genetic diagnosis provides net economic benefits when used by carrier couples of CF. Although there is an upper limit of maternal age at which economic benefit can be demonstrated, carrier couples of CF should be offered PGD for prevention of an affected child.<br /> (Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Abortion, Spontaneous economics
Abortion, Spontaneous epidemiology
Adult
Algorithms
Blastocyst cytology
Cost-Benefit Analysis
Cystic Fibrosis economics
Female
Fertilization in Vitro economics
Genetic Carrier Screening methods
Heterozygote
Humans
Male
Pregnancy
Pregnancy Rate
Pregnancy, Multiple genetics
Pregnancy, Multiple physiology
Twins
Cystic Fibrosis diagnosis
Cystic Fibrosis genetics
Preimplantation Diagnosis economics
Subjects
Details
- Language :
- English
- ISSN :
- 1556-5653
- Volume :
- 93
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Fertility and sterility
- Publication Type :
- Academic Journal
- Accession number :
- 19439290
- Full Text :
- https://doi.org/10.1016/j.fertnstert.2008.12.053