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Cross-reactive memory CD4+ T cells alter the CD8+ T-cell response to heterologous secondary dengue virus infections in mice in a sequence-specific manner.
- Source :
-
Viral immunology [Viral Immunol] 2009 Jun; Vol. 22 (3), pp. 215-9. - Publication Year :
- 2009
-
Abstract
- Secondary dengue virus (DENV) infection is a major factor contributing to the risk for severe disease, an effect that depends upon the sequence of infection with different DENV serotypes. We previously reported sequence-dependent effects of secondary DENV infection on CD8+ T-cell responses in mice. To further evaluate the effect of infection sequence, we analyzed DENV-specific CD4+ T-cell responses and their relationship to the CD8+ T-cell response. Serotype cross-reactivity of CD4+ T-cell responses also depended upon the sequence of serotypes in this model. Furthermore, adoptive transfer of memory CD4+ T cells altered the response of memory CD8+ T cells to secondary infection. These data demonstrate the interaction of different components of the T-cell response in determining the immunological outcome of secondary DENV infection.
Details
- Language :
- English
- ISSN :
- 1557-8976
- Volume :
- 22
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Viral immunology
- Publication Type :
- Academic Journal
- Accession number :
- 19435418
- Full Text :
- https://doi.org/10.1089/vim.2008.0089