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Cerebrospinal fluid biomarkers and rate of cognitive decline in very mild dementia of the Alzheimer type.
- Source :
-
Archives of neurology [Arch Neurol] 2009 May; Vol. 66 (5), pp. 638-45. - Publication Year :
- 2009
-
Abstract
- Background: Cerebrospinal fluid (CSF) levels of Abeta peptide 1-42 (Abeta 42), tau, and phosphorylated tau (ptau) are potential biomarkers of Alzheimer disease.<br />Objective: To determine whether Abeta 42, tau, and ptau predict the rate of cognitive change in individuals with very mild dementia of the Alzheimer type (DAT).<br />Design: Retrospective analysis of CSF biomarkers and clinical data.<br />Setting: An academic Alzheimer disease research center.<br />Participants: Research volunteers in a longitudinal study of aging and cognition. Participants (n = 49) had a clinical diagnosis of very mild DAT with a Clinical Dementia Rating (CDR) of 0.5 at the time of lumbar puncture. All the participants had at least 1 follow-up assessment (mean [SD] follow-up, 3.5 [1.8] years).<br />Main Outcome Measures: Baseline CSF levels of Abeta 42, Abeta 40, tau, and ptau at threonine 181 (ptau181) and the rate of dementia progression as measured using the CDR sum of boxes (CDR-SB) score and psychometric performance.<br />Results: The rate of dementia progression was significantly more rapid in individuals with lower baseline CSF Abeta 42 levels, higher tau or ptau181 levels, or high tau: Abeta 42 ratios. For example, the annual change in the CDR-SB score was 1.1 for the lowest 2 tertiles of Abeta 42 values and 0.3 for the highest tertile of Abeta 42 values.<br />Conclusions: In individuals with very mild DAT, lower CSF Abeta 42 levels, high tau or ptau181 levels, or high tau:Abeta 42 ratios quantitatively predict more rapid progression of cognitive deficits and dementia. Biomarkers of CSF may be useful prognostically and to identify individuals who are more likely to progress for participation in therapeutic clinical trials.
- Subjects :
- Aged
Aged, 80 and over
Alzheimer Disease psychology
Amyloid beta-Peptides analysis
Biomarkers analysis
Biomarkers cerebrospinal fluid
Brain metabolism
Brain pathology
Brain physiopathology
Cognition Disorders psychology
Disease Progression
Female
Humans
Longitudinal Studies
Male
Middle Aged
Neurofibrillary Tangles metabolism
Neurofibrillary Tangles pathology
Peptide Fragments analysis
Plaque, Amyloid metabolism
Plaque, Amyloid pathology
Predictive Value of Tests
Prognosis
Retrospective Studies
tau Proteins analysis
Alzheimer Disease cerebrospinal fluid
Alzheimer Disease physiopathology
Amyloid beta-Peptides cerebrospinal fluid
Cognition Disorders cerebrospinal fluid
Cognition Disorders physiopathology
Peptide Fragments cerebrospinal fluid
tau Proteins cerebrospinal fluid
Subjects
Details
- Language :
- English
- ISSN :
- 1538-3687
- Volume :
- 66
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Archives of neurology
- Publication Type :
- Academic Journal
- Accession number :
- 19433664
- Full Text :
- https://doi.org/10.1001/archneurol.2009.55