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MALT lymphoma of the thymus with Sjögren's syndrome: biphasic changes in serological abnormalities over a 4-year period following thymectomy.
- Source :
-
International journal of hematology [Int J Hematol] 2009 Jun; Vol. 89 (5), pp. 709-13. Date of Electronic Publication: 2009 May 09. - Publication Year :
- 2009
-
Abstract
- Thymic mucosa-associated lymphoid tissue (MALT) lymphoma shows distinct immunological characteristics, such as the expression of the IgA isotype, the frequent presence of immunoglobulin abnormalities, and a strong association with autoimmune disease, especially Sjögren's syndrome (SjS). We report a case of thymic MALT lymphoma, who exhibited biphasic changes in her clinical characteristics during the 4-year observation period after thymectomy. A 71-year-old woman was admitted because of suspected SjS. A diagnosis of primary thymic MALT lymphoma was made, and SjS was confirmed. Serological abnormalities such as polyclonal hypergammaglobulinemia, IgA M protein, and elevated levels of rheumatoid factor were noted. These abnormalities improved rapidly after the thymectomy, but did not completely disappear. Interestingly, the remaining abnormalities, which can be ascribed to the proliferation of B cells throughout the body under the influence of SjS, have been improving slowly but steadily during the 4-year observation period. It is suspected that the removal of the tumor by thymectomy has more or less normalized the immunological environment and alleviated the SjS disease activity.
- Subjects :
- Aged
B-Lymphocytes pathology
Female
Humans
Lymphoma, B-Cell, Marginal Zone diagnosis
Lymphoma, B-Cell, Marginal Zone surgery
Thymectomy
Thyroid Neoplasms diagnosis
Thyroid Neoplasms surgery
Treatment Outcome
Lymphoma, B-Cell, Marginal Zone complications
Sjogren's Syndrome diagnosis
Thyroid Neoplasms complications
Subjects
Details
- Language :
- English
- ISSN :
- 1865-3774
- Volume :
- 89
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- International journal of hematology
- Publication Type :
- Academic Journal
- Accession number :
- 19430860
- Full Text :
- https://doi.org/10.1007/s12185-009-0324-3