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RecBCD and RecFOR dependent induction of chromosomal deletions by sodium selenite in Salmonella.
- Source :
-
Mutation research [Mutat Res] 2009 Jun 01; Vol. 665 (1-2), pp. 14-9. Date of Electronic Publication: 2009 Mar 09. - Publication Year :
- 2009
-
Abstract
- RecBCD and RecFOR homologous recombination pathways induced bacterial chromosomal duplication-segregation by sodium selenite (SSe) at sub-inhibitory concentrations. This evidence suggests that SSe induces both, double and single DNA strand damage with a concomitant DNA repair response, however the strong dependence for recombinogenic activity of RecB product suggests that the main DNA repair pathway copes with dsDNA breaks. A role for SSe recombinogenic induction is proposed to explain its effect on DNA instability.
- Subjects :
- Bacterial Proteins metabolism
DNA Damage
DNA Repair
DNA-Binding Proteins metabolism
Genes, Bacterial
Recombination, Genetic
Salmonella typhimurium metabolism
Chromosome Deletion
Chromosomes, Bacterial drug effects
Chromosomes, Bacterial genetics
Exodeoxyribonuclease V metabolism
Salmonella typhimurium drug effects
Salmonella typhimurium genetics
Sodium Selenite toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 0027-5107
- Volume :
- 665
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Mutation research
- Publication Type :
- Academic Journal
- Accession number :
- 19427506
- Full Text :
- https://doi.org/10.1016/j.mrfmmm.2009.02.012