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Homology modeling in drug discovery: current trends and applications.
- Source :
-
Drug discovery today [Drug Discov Today] 2009 Jul; Vol. 14 (13-14), pp. 676-83. Date of Electronic Publication: 2009 May 05. - Publication Year :
- 2009
-
Abstract
- As structural genomics (SG) projects continue to deposit representative 3D structures of proteins, homology modeling methods will play an increasing role in structure-based drug discovery. Although computational structure prediction methods provide a cost-effective alternative in the absence of experimental structures, developing accurate enough models still remains a big challenge. In this contribution, we report the current developments in this field, discuss in silico modeling limitations, and review the successful application of this technique to different stages of the drug discovery process.
Details
- Language :
- English
- ISSN :
- 1878-5832
- Volume :
- 14
- Issue :
- 13-14
- Database :
- MEDLINE
- Journal :
- Drug discovery today
- Publication Type :
- Academic Journal
- Accession number :
- 19422931
- Full Text :
- https://doi.org/10.1016/j.drudis.2009.04.006