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An African perspective on mucosal immunity and HIV-1.

Authors :
Pala P
Gomez-Roman VR
Gilmour J
Kaleebu P
Source :
Mucosal immunology [Mucosal Immunol] 2009 Jul; Vol. 2 (4), pp. 300-14. Date of Electronic Publication: 2009 May 06.
Publication Year :
2009

Abstract

HIV prevention mandates an understanding of the mechanisms of mucosal immunity with attention to some unique features of the epidemic and mucosal environment in the developing world. An effective vaccine will have to induce mucosal protection against a highly diverse virus, which is equipped with a number of immune evasion strategies. Its development will require assessment of mucosal immune responses, and it will have to protect a mucosal environment where inflammation and altered immune responses are common because of the presence of other mucosal infections, such as sexually transmitted infections and parasites, and where nutritional status may also be compromised. Ideally, not only prevention methods would protect adults but also provide cover against gastrointestinal transmission through maternal milk. Prevention might also be complemented by microbicides and circumcision, two alternative approaches to mucosal protection. It seems unlikely that a single solution will work in all instances and intervention might have to act at multiple levels and be tailored to local circumstances. We review here some of the mucosal events associated with HIV infection that are most relevant in an African setting.

Details

Language :
English
ISSN :
1935-3456
Volume :
2
Issue :
4
Database :
MEDLINE
Journal :
Mucosal immunology
Publication Type :
Academic Journal
Accession number :
19421180
Full Text :
https://doi.org/10.1038/mi.2009.23