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Loss of inhibition over master pathways of bone mass regulation results in osteosclerotic bone metastases in prostate cancer.
- Source :
-
Swiss medical weekly [Swiss Med Wkly] 2009 Apr 18; Vol. 139 (15-16), pp. 220-5. - Publication Year :
- 2009
-
Abstract
- Prostate cancer is the most common cancer among men in industrialised countries. Most patients with prostate cancer, however, will not die of it. As a result, many of them will experience symptomatic metastasis during the course of the disease. Prostate cancer has a high propensity to metastasize to bone. Unlike many other cancers prostate cancer cells induce a rather osteosclerotic than osteolytic reaction in the bone marrow by interfering with physiological bone remodelling. A proper understanding of the mechanisms of tumour cell-induced bone alterations and exaggerated bone deposition in prostate cancer may open new and urgently needed therapeutic approaches in the field of palliative care for affected patients. In this review we focus on the central role of two major regulators of bone mass, the wingless type integration site family members (WNTs) and the bone morphogenetic proteins (BMPs), in the development of osteosclerotic bone metastases.
- Subjects :
- Animals
Bone Morphogenetic Proteins antagonists & inhibitors
Bone Remodeling physiology
Carrier Proteins pharmacology
Humans
Male
Models, Animal
Osteoblasts physiology
Osteosclerosis etiology
Osteosclerosis pathology
Bone Morphogenetic Proteins physiology
Bone Neoplasms physiopathology
Bone Neoplasms secondary
Osteosclerosis physiopathology
Prostatic Neoplasms pathology
Signal Transduction physiology
Wnt Proteins physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1424-7860
- Volume :
- 139
- Issue :
- 15-16
- Database :
- MEDLINE
- Journal :
- Swiss medical weekly
- Publication Type :
- Academic Journal
- Accession number :
- 19418305
- Full Text :
- https://doi.org/smw-12284