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Clinicopathological significance of stanniocalcin 2 gene expression in colorectal cancer.
- Source :
-
International journal of cancer [Int J Cancer] 2009 Aug 15; Vol. 125 (4), pp. 926-31. - Publication Year :
- 2009
-
Abstract
- Laser microdissection (LMD) and microarray were used to identify genes associated with colorectal cancer. Stanniocalcin 2 (STC2) expression and clinicopathological significance in 139 clinical colorectal cancer samples were specifically investigated using real-time quantitative reverse transcription-polymerase chain reaction. A number of genes upregulated in colorectal cancer cells compared to normal colorectal epithelial cells were identified including STC2. STC2 gene expression in cancer tissue was higher than in corresponding normal colorectal epithelial tissue in 124 of 139 cases (89.2%, p < 0.01). Tumors with high STC2 expression showed higher frequencies of lymph node metastasis, lymphatic invasion, tumor depth, tumor size and AJCC Stage classification (p < 0.01). Patients with high STC2 expression also showed significantly worse overall survival rates than those with low STC2 expression (p < 0.01). Furthermore, STC2 gene appeared to be associated with colorectal cancer progression and may be a useful prognostic indicator for colorectal cancer.
- Subjects :
- Aged
Biomarkers, Tumor genetics
Biomarkers, Tumor metabolism
Calcium metabolism
Case-Control Studies
Colon metabolism
Colon pathology
Colorectal Neoplasms metabolism
Colorectal Neoplasms pathology
Female
Gene Expression Profiling
Glycoproteins metabolism
Humans
Immunoenzyme Techniques
Intercellular Signaling Peptides and Proteins metabolism
Lasers
Liver Neoplasms metabolism
Liver Neoplasms secondary
Lymphatic Metastasis
Male
Microdissection
Oligonucleotide Array Sequence Analysis
RNA, Messenger genetics
RNA, Messenger metabolism
Rectum metabolism
Rectum pathology
Reverse Transcriptase Polymerase Chain Reaction
Survival Rate
Colorectal Neoplasms genetics
Glycoproteins genetics
Intercellular Signaling Peptides and Proteins genetics
Liver Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0215
- Volume :
- 125
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- International journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 19415750
- Full Text :
- https://doi.org/10.1002/ijc.24453