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Quality of life and seizure control in patients with brain tumor-related epilepsy treated with levetiracetam monotherapy: preliminary data of an open-label study.
- Source :
-
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2009 Aug; Vol. 30 (4), pp. 353-9. Date of Electronic Publication: 2009 May 05. - Publication Year :
- 2009
-
Abstract
- The aim of this pilot study was to investigate the effects of levetiracetam monotherapy on seizure control, quality of life and neurocognitive performance in patients with brain tumor-related epilepsy. We present here preliminary data from 18 patients with follow-up of 6 months. We evaluated seizure frequency at baseline. We used administered Mini Mental State Examination (MMSE), Karnofsky Performance Status (KPS), Barthel index (BI), QOLIE 31P (V2), EORTC QLQ-C30 and Adverse Events Profile. After 6 months, 16 patients were seizure free (88.9%), 2 (11.1%) had reduction in seizure frequency >50%. Compared to baseline, we observed a worsening of performance (KPS p = 0.011; BI = 0.008) and global lower cognitive performance (MMSE p = 0.011); distress related to seizure frequency (p = 0.003) and medication effects (p = 0.046) were significantly lower. Levetiracetam caused mild and reversible side effects. These preliminary data on LEV monotherapy in patients with brain tumor-related epilepsy show that this antiepileptic drug is efficacious and well tolerated.
- Subjects :
- Activities of Daily Living
Adult
Aged
Anticonvulsants adverse effects
Blood Cell Count
Brain Neoplasms therapy
Combined Modality Therapy
Female
Humans
Karnofsky Performance Status
Levetiracetam
Logistic Models
Male
Middle Aged
Neuropsychological Tests
Personal Autonomy
Piracetam adverse effects
Piracetam therapeutic use
Surveys and Questionnaires
Young Adult
Anticonvulsants therapeutic use
Brain Neoplasms complications
Epilepsy drug therapy
Epilepsy etiology
Piracetam analogs & derivatives
Quality of Life
Seizures drug therapy
Seizures etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1590-3478
- Volume :
- 30
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
- Publication Type :
- Academic Journal
- Accession number :
- 19415165
- Full Text :
- https://doi.org/10.1007/s10072-009-0087-x