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Autoimmunity: CTLA-4: a key protein in autoimmunity.
- Source :
-
Nature reviews. Rheumatology [Nat Rev Rheumatol] 2009 May; Vol. 5 (5), pp. 244-5. - Publication Year :
- 2009
-
Abstract
- Studies performed during the past 2 years have provided a deeper understanding into the role of CTLA-4, which is expressed on regulatory T cells, in preventing autoimmunity, and also provide mechanistic insight into protein-based therapeutics such as abatacept for rheumatic diseases.
- Subjects :
- B7-1 Antigen metabolism
B7-2 Antigen metabolism
CTLA-4 Antigen
Dendritic Cells immunology
Dendritic Cells metabolism
Humans
Lymphocyte Activation
Signal Transduction
T-Lymphocytes, Cytotoxic metabolism
T-Lymphocytes, Regulatory metabolism
Antigens, CD physiology
Autoimmunity physiology
T-Lymphocytes, Cytotoxic immunology
T-Lymphocytes, Regulatory immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1759-4804
- Volume :
- 5
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Nature reviews. Rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 19412189
- Full Text :
- https://doi.org/10.1038/nrrheum.2009.77