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Effect of subconjunctival bevacizumab on primary pterygium.

Authors :
Teng CC
Patel NN
Jacobson L
Source :
Cornea [Cornea] 2009 May; Vol. 28 (4), pp. 468-70.
Publication Year :
2009

Abstract

Purpose: To investigate the effect of subconjunctival bevacizumab on primary pterygium.<br />Methods: A patient with an inflamed nasal primary pterygium, refractory to artificial tears and naphazoline, was enrolled in this study. After pretreatment with topical proparacaine and moxifloxacin, 0.05 mL of bevacizumab (1.25 mg/0.05 mL) was injected subconjunctivally at the limbus. Clinical signs of irritation, redness, and vascularization were monitored over 7 weeks.<br />Results: At 1 week postinjection, irritation and hyperemia showed near-total regression. At week 2, the pterygium maintained this appearance. By week 7, the degree of vascularity and symptoms of irritation had regressed to its preinjection state.<br />Conclusions: Treatment of primary pterygium with subconjunctival bevacizumab results in a short-term decrease in vascularization and irritation. Further long-term studies should investigate the efficacy of bevacizumab as an adjunct to surgical excision or combined topical treatment targeting other growth factors involved in pterygium pathogenesis.

Details

Language :
English
ISSN :
1536-4798
Volume :
28
Issue :
4
Database :
MEDLINE
Journal :
Cornea
Publication Type :
Academic Journal
Accession number :
19411971
Full Text :
https://doi.org/10.1097/ICO.0b013e31818d382d