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The gastric ulcer-healing action of allylpyrocatechol is mediated by modulation of arginase metabolism and shift of cytokine balance.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 2009 Jul 01; Vol. 614 (1-3), pp. 106-13. Date of Electronic Publication: 2009 May 03. - Publication Year :
- 2009
-
Abstract
- The role of the ariginine-metabolism in the healing action of the Piper betle phenol, allylpyrocatechol (APC) and omeprazole against indomethacin-induced stomach ulceration in mouse was investigated. Indomethacin (18 mg/kg) was found to induce maximum stomach ulceration in Swiss albino mice on the 3rd day of its administration, which was associated with reduced arginase activity (21.6%, P<0.05), endothelial nitric oxide synthase (eNOS) expression (72%, P<0.001), and IL-4 and TGF-beta levels, along with increased inducible nitric oxide synthase (iNOS) (9.3 folds, P<0.001) expression, nitrite (2.29 folds, P<0.001), IL-1beta and IL-6 generation. Besides providing comparable healing as omeprazole (3 mg/kg x 3 days), APC (5 mg/kg x 3 days) shifted the iNOS/NO axis to the arginase/polyamine axis as revealed from the increased arginase activity (73.1%, P<0.001), eNOS expression (67.8%, P<0.001), and reduced iNOS expression (65.6%, P<0.001) and nitrite level (53.2%, P<0.001). These can be attributed to a favourable anti-/pro-inflammatory cytokines ratio, generated by APC. The healing by omeprazole was however, not significantly associated with those parameters.
- Subjects :
- Animals
Anti-Inflammatory Agents metabolism
Arginine metabolism
Cytokines blood
Gene Expression Regulation, Enzymologic drug effects
Male
Mice
Mucous Membrane drug effects
Mucous Membrane enzymology
Mucous Membrane metabolism
Nitric Oxide biosynthesis
Nitric Oxide Synthase metabolism
Nitrites blood
Peroxidase metabolism
Stomach Ulcer blood
Stomach Ulcer enzymology
Stomach Ulcer metabolism
Arginase metabolism
Catechols pharmacology
Catechols therapeutic use
Cytokines metabolism
Stomach Ulcer drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0712
- Volume :
- 614
- Issue :
- 1-3
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 19409889
- Full Text :
- https://doi.org/10.1016/j.ejphar.2009.04.046