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Synthesis of novel cholesterol-based cationic lipids for gene delivery.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 Jun 01; Vol. 19 (11), pp. 2986-9. Date of Electronic Publication: 2009 Apr 18. - Publication Year :
- 2009
-
Abstract
- The new cholesterol-based cationic lipids B, C, and D with an ether linked spacer were synthesized by using aminopropyl chain extension with acrylonitrile. The cholesterol-based cationic lipid A with carbamoyl linkage were also synthesized in order to compare the difference in transfection efficiency of the two linkage types. To this end, GFP expression of these cationic lipids was confirmed respectively.
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 19
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 19409781
- Full Text :
- https://doi.org/10.1016/j.bmcl.2009.04.036