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The anti-interleukin-1 in type 1 diabetes action trial--background and rationale.
- Source :
-
Diabetes/metabolism research and reviews [Diabetes Metab Res Rev] 2009 May; Vol. 25 (4), pp. 321-4. - Publication Year :
- 2009
-
Abstract
- Type 1 diabetes (T1D) is caused by an inflammatory destruction of pancreatic beta-cells. Pro-inflammatory cytokines, in particular interleukin-1 (IL-1), have been suggested to be effector molecules based on the observations that pro-inflammatory cytokines cause beta-cell apoptosis in vitro and aggravate diabetes in vivo, and that inhibition of the action of these cytokines reduce diabetes incidence in animal models of type 1 diabetes and islet graft destruction. This review presents the rationale for and design of a recently launched double-blind, multicenter, randomized clinical trial that investigates the effect of interleukin-1 antagonism on beta-cell function in subjects with T1D of recent-onset.
- Subjects :
- Animals
Child
Diabetes Mellitus, Type 1 immunology
Double-Blind Method
Humans
Insulin-Secreting Cells immunology
Multicenter Studies as Topic methods
Research Design
Diabetes Mellitus, Type 1 drug therapy
Immunologic Factors therapeutic use
Insulin-Secreting Cells drug effects
Interleukin 1 Receptor Antagonist Protein therapeutic use
Interleukin-1 antagonists & inhibitors
Randomized Controlled Trials as Topic methods
Subjects
Details
- Language :
- English
- ISSN :
- 1520-7560
- Volume :
- 25
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Diabetes/metabolism research and reviews
- Publication Type :
- Academic Journal
- Accession number :
- 19405081
- Full Text :
- https://doi.org/10.1002/dmrr.960