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A biometric latent curve analysis of memory decline in older men of the NAS-NRC twin registry.
- Source :
-
Behavior genetics [Behav Genet] 2009 Sep; Vol. 39 (5), pp. 472-95. Date of Electronic Publication: 2009 Apr 29. - Publication Year :
- 2009
-
Abstract
- Previous research has shown cognitive abilities to have different biometric patterns of age-changes. We examined the variation in episodic memory (word recall task) for over 6,000 twin pairs who were initially aged 59-75, and were subsequently re-assessed up to three more times over 12 years. In cross-sectional analyses, variation in the number of words recalled independent of age was explained largely by non-shared influences (65-72%), with clear additive genetic influences (12-32%), and marginal shared family influences (1-18%). The longitudinal phenotypic analysis of the word recall task showed systematic linear declines over age, but several nonlinear models with more dramatic changes at later ages, improved the overall fit. A two-part spline model for the longitudinal twin data with an optimal turning point at age 74 led to: (a) a separation of non-shared environmental influences and transient measurement error (~50%); (b) strong additive genetic components of this latent curve (~44% at age 60) with increases (over 50%) up to age 74, but with no additional genetic variation after age 74; (c) the smaller influences of shared family environment (~15% at age 74) were constant over all ages; (d) non-shared effects play an important role over most of the life-span but diminish after age 74.
Details
- Language :
- English
- ISSN :
- 1573-3297
- Volume :
- 39
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Behavior genetics
- Publication Type :
- Academic Journal
- Accession number :
- 19404731
- Full Text :
- https://doi.org/10.1007/s10519-009-9272-1