Back to Search
Start Over
Fibrils of prostatic acid phosphatase fragments boost infections with XMRV (xenotropic murine leukemia virus-related virus), a human retrovirus associated with prostate cancer.
- Source :
-
Journal of virology [J Virol] 2009 Jul; Vol. 83 (14), pp. 6995-7003. Date of Electronic Publication: 2009 Apr 29. - Publication Year :
- 2009
-
Abstract
- The xenotropic murine leukemia virus-related virus (XMRV) has recently been detected in prostate cancer tissues and may play a role in tumorigenesis. It is currently unclear how this virus is transmitted and which factors promote its spread in the prostate. We show that amyloidogenic fragments known as semen-derived enhancer of virus infection (SEVI) originating from prostatic acid phosphatase greatly increase XMRV infections of primary prostatic epithelial and stromal cells. Hybrid simian/human immunodeficiency chimeric virus particles pseudotyped with XMRV envelope protein were used to demonstrate that the enhancing effect of SEVI, or of human semen itself, was at the level of viral attachment and entry. SEVI enhanced XMRV infectivity but did not bypass the requirement for the xenotropic and polytropic retrovirus receptor 1. Furthermore, XMRV RNA was detected in prostatic secretions of some men with prostate cancer. The fact that the precursor of SEVI is produced in abundance by the prostate indicates that XMRV replication occurs in an environment that provides a natural enhancer of viral infection, and this may play a role in the spread of this virus in the human population.
- Subjects :
- Acid Phosphatase
Cell Line, Tumor
Cells, Cultured
Fibroblasts enzymology
Fibroblasts virology
Gammaretrovirus genetics
Humans
Male
Protein Tyrosine Phosphatases genetics
Gammaretrovirus physiology
Prostatic Neoplasms enzymology
Prostatic Neoplasms virology
Protein Tyrosine Phosphatases metabolism
Retroviridae Infections enzymology
Retroviridae Infections virology
Subjects
Details
- Language :
- English
- ISSN :
- 1098-5514
- Volume :
- 83
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Journal of virology
- Publication Type :
- Academic Journal
- Accession number :
- 19403677
- Full Text :
- https://doi.org/10.1128/JVI.00268-09