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A postnatal critical period for orientation plasticity in the cat visual cortex.
- Source :
-
PloS one [PLoS One] 2009; Vol. 4 (4), pp. e5380. Date of Electronic Publication: 2009 Apr 29. - Publication Year :
- 2009
-
Abstract
- Orientation selectivity of primary visual cortical neurons is an important requisite for shape perception. Although numerous studies have been previously devoted to a question of how orientation selectivity is established and elaborated in early life, how the susceptibility of orientation plasticity to visual experience changes in time remains unclear. In the present study, we showed a postnatal sensitive period profile for the modifiability of orientation selectivity in the visual cortex of kittens reared with head-mounted goggles for stable single-orientation exposure. When goggle rearing (GR) started at P16-P30, 2 weeks of GR induced a marked over-representation of the exposed orientation, and 2 more weeks of GR consolidated the altered orientation maps. GR that started later than P50, in turn, induced the under-representation of the exposed orientation. Orientation plasticity in the most sensitive period was markedly suppressed by cortical infusion of NMDAR antagonist. The present study reveals that the plasticity and consolidation of orientation selectivity in an early life are dynamically regulated in an experience-dependent manner.
- Subjects :
- 2-Amino-5-phosphonovalerate administration & dosage
Age Factors
Animals
Cats
Neuronal Plasticity drug effects
Orientation drug effects
Photic Stimulation
Receptors, N-Methyl-D-Aspartate antagonists & inhibitors
Receptors, N-Methyl-D-Aspartate physiology
Visual Cortex drug effects
Neuronal Plasticity physiology
Orientation physiology
Visual Cortex growth & development
Visual Cortex physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 4
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 19401781
- Full Text :
- https://doi.org/10.1371/journal.pone.0005380