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Synergistic effects of ovine-derived cathelicidins and other antimicrobials against Escherichia coli O157:H7 and Staphylococcus aureus 1056 MRSA.
- Source :
-
Biotechnology letters [Biotechnol Lett] 2009 Aug; Vol. 31 (8), pp. 1265-7. Date of Electronic Publication: 2009 Apr 26. - Publication Year :
- 2009
-
Abstract
- Synergistic effects of ovine-derived cathelicidins SMAP29 and OaBac5mini with the antimicrobials polymyxin B, lysozyme, nisin and lactoferrin were investigated against E. coli O157:H7 and S. aureus 1056 MRSA. Lysozyme showed synergy against E. coli O157:H7 with SMAP29, polymyxin B and lactoferrin. Synergy was also found between SMAP29 and lactoferrin against this host. Against S. aureus 1056 MRSA, lysozyme showed synergy with OaBac5mini, polymyxin B and nisin, while synergy was also found between nisin and OaBac5mini and polymyxin B. Other combinations of the antimicrobials were either additive or non-synergistic.
- Subjects :
- Cathelicidins
Drug Synergism
Microbial Sensitivity Tests
Anti-Bacterial Agents pharmacology
Blood Proteins pharmacology
Escherichia coli O157 drug effects
Lactoferrin pharmacology
Methicillin-Resistant Staphylococcus aureus drug effects
Muramidase pharmacology
Nisin pharmacology
Polymyxin B pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-6776
- Volume :
- 31
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Biotechnology letters
- Publication Type :
- Academic Journal
- Accession number :
- 19396584
- Full Text :
- https://doi.org/10.1007/s10529-009-0010-9