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Chemical composition and in vitro anti-inflammatory activity of apple phenolic extracts and of their sub-fractions.
- Source :
-
International journal of food sciences and nutrition [Int J Food Sci Nutr] 2009; Vol. 60 Suppl 7, pp. 188-205. Date of Electronic Publication: 2009 Apr 23. - Publication Year :
- 2009
-
Abstract
- Apple extract powders from three different manufacturers were investigated for their anti-inflammatory activity, their total phenolic content, and their chemical composition. The samples represented two production batches for two products and a single batch of a third. The samples showed similar, but clearly different, anti-inflammatory activities, and had substantially different total phenolic contents, and different chemical compositions. Differences in chemical composition for batches of the same product were significant, although not as great as differences between products. The samples were fractionated into chemical classes. The most active fractions were those that contained epicatechin, catechin with phloridzin and quercetin glycosides, or those that contained procyanidin polymers. It was not possible to link activity to the presence of individual components or combinations of these. If fruit extracts are to be reliably linked to validated health benefits, then the source materials, the extraction processes, and the final composition of such products need to be more clearly defined than at present.
- Subjects :
- Animals
Cell Line
Cell Survival drug effects
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Flavonoids analysis
Flavonoids chemistry
Flavonoids pharmacology
Glycosides analysis
Glycosides chemistry
Glycosides pharmacology
Inflammation drug therapy
Inflammation Mediators metabolism
Inhibitory Concentration 50
Lipopolysaccharides toxicity
Macrophages drug effects
Macrophages metabolism
Mice
Phenols chemistry
Phenols pharmacology
Phytotherapy
Powders
Reproducibility of Results
Anti-Inflammatory Agents, Non-Steroidal chemistry
Anti-Inflammatory Agents, Non-Steroidal pharmacology
Fruit chemistry
Malus chemistry
Phenols analysis
Plant Extracts chemistry
Plant Extracts pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1465-3478
- Volume :
- 60 Suppl 7
- Database :
- MEDLINE
- Journal :
- International journal of food sciences and nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 19391030
- Full Text :
- https://doi.org/10.1080/09637480902849203