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In vitro activity of voriconazole against Mexican oral yeast isolates.

Authors :
Sánchez Vargas LO
Eraso E
Carrillo-Muñoz AJ
Aguirre JM
Gaitán-Cepeda LA
Quindós G
Source :
Mycoses [Mycoses] 2010 May; Vol. 53 (3), pp. 200-3. Date of Electronic Publication: 2009 Mar 07.
Publication Year :
2010

Abstract

Oral candidiasis is the most prevalent complication in HIV-infected and AIDS patients. Topical antifungal treatment is useful for the initial episodes of oral candidiasis, but most patients suffer more than one episode and fluconazole or itraconazole can help in the management, and voriconazole may represent a useful alternative agent for the treatment of recalcitrant oral and oesophageal candidiasis. The aim of this research was to study the in vitro activity of voriconazole and fluconazole against Mexican oral isolates of clinically relevant yeast. The in vitro susceptibility of 187 oral yeast isolates from HIV-infected and healthy Mexicans was determined for fluconazole and voriconazole by the M44-A disc diffusion method. At 24 h, fluconazole was active against 179 of 187 isolates (95.7 %). Moreover, a 100% susceptibility to voriconazole was observed. Voriconazole and fluconazole are highly active in vitro against oral yeast isolates. This study provides baseline data on susceptibilities to both antifungal agents in Mexico.

Details

Language :
English
ISSN :
1439-0507
Volume :
53
Issue :
3
Database :
MEDLINE
Journal :
Mycoses
Publication Type :
Academic Journal
Accession number :
19389066
Full Text :
https://doi.org/10.1111/j.1439-0507.2009.01702.x