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In vitro activity of voriconazole against Mexican oral yeast isolates.
- Source :
-
Mycoses [Mycoses] 2010 May; Vol. 53 (3), pp. 200-3. Date of Electronic Publication: 2009 Mar 07. - Publication Year :
- 2010
-
Abstract
- Oral candidiasis is the most prevalent complication in HIV-infected and AIDS patients. Topical antifungal treatment is useful for the initial episodes of oral candidiasis, but most patients suffer more than one episode and fluconazole or itraconazole can help in the management, and voriconazole may represent a useful alternative agent for the treatment of recalcitrant oral and oesophageal candidiasis. The aim of this research was to study the in vitro activity of voriconazole and fluconazole against Mexican oral isolates of clinically relevant yeast. The in vitro susceptibility of 187 oral yeast isolates from HIV-infected and healthy Mexicans was determined for fluconazole and voriconazole by the M44-A disc diffusion method. At 24 h, fluconazole was active against 179 of 187 isolates (95.7 %). Moreover, a 100% susceptibility to voriconazole was observed. Voriconazole and fluconazole are highly active in vitro against oral yeast isolates. This study provides baseline data on susceptibilities to both antifungal agents in Mexico.
- Subjects :
- Adult
Candida classification
Candida isolation & purification
Fluconazole pharmacology
HIV Infections complications
Humans
Mexico
Microbial Sensitivity Tests
Mouth microbiology
Pharynx microbiology
Voriconazole
Antifungal Agents pharmacology
Candida drug effects
Candidiasis, Oral microbiology
Pyrimidines pharmacology
Triazoles pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1439-0507
- Volume :
- 53
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Mycoses
- Publication Type :
- Academic Journal
- Accession number :
- 19389066
- Full Text :
- https://doi.org/10.1111/j.1439-0507.2009.01702.x