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Vitamin K supplementation and progression of coronary artery calcium in older men and women.
- Source :
-
The American journal of clinical nutrition [Am J Clin Nutr] 2009 Jun; Vol. 89 (6), pp. 1799-807. Date of Electronic Publication: 2009 Apr 22. - Publication Year :
- 2009
-
Abstract
- Background: Coronary artery calcification (CAC) is an independent predictor of cardiovascular disease. A preventive role for vitamin K in CAC progression has been proposed on the basis of the properties of matrix Gla protein (MGP) as a vitamin K-dependent calcification inhibitor.<br />Objective: The objective was to determine the effect of phylloquinone (vitamin K1) supplementation on CAC progression in older men and women.<br />Design: CAC was measured at baseline and after 3 y of follow-up in 388 healthy men and postmenopausal women; 200 received a multivitamin with 500 microg phylloquinone/d (treatment), and 188 received a multivitamin alone (control).<br />Results: In an intention-to-treat analysis, there was no difference in CAC progression between the phylloquinone group and the control group; the mean (+/-SEM) changes in Agatston scores were 27 +/- 6 and 37 +/- 7, respectively. In a subgroup analysis of participants who were > or =85% adherent to supplementation (n = 367), there was less CAC progression in the phylloquinone group than in the control group (P = 0.03). Of those with preexisting CAC (Agatston score > 10), those who received phylloquinone supplements had 6% less progression than did those who received the multivitamin alone (P = 0.04). Phylloquinone-associated decreases in CAC progression were independent of changes in serum MGP. MGP carboxylation status was not determined.<br />Conclusions: Phylloquinone supplementation slows the progression of CAC in healthy older adults with preexisting CAC, independent of its effect on total MGP concentrations. Because our data are hypothesis-generating, further studies are warranted to clarify this mechanism. This trial was registered at clinicaltrials.gov as NCT00183001.
- Subjects :
- Aged
C-Reactive Protein metabolism
Calcinosis diagnostic imaging
Calcinosis prevention & control
Calcium blood
Coronary Angiography
Coronary Vessels chemistry
Double-Blind Method
Female
Humans
Interleukin-6 blood
Male
Middle Aged
Osteoprotegerin blood
Postmenopause
Vitamin K administration & dosage
Vitamin K pharmacology
Vitamins administration & dosage
Vitamins pharmacology
Matrix Gla Protein
Calcinosis drug therapy
Calcium analysis
Calcium-Binding Proteins blood
Coronary Vessels drug effects
Dietary Supplements
Extracellular Matrix Proteins blood
Vitamin K therapeutic use
Vitamins therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1938-3207
- Volume :
- 89
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The American journal of clinical nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 19386744
- Full Text :
- https://doi.org/10.3945/ajcn.2008.27338