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Expression of cripto, a novel gene of the epidermal growth factor family, in human gastrointestinal carcinomas.
- Source :
-
Japanese journal of cancer research : Gann [Jpn J Cancer Res] 1991 Sep; Vol. 82 (9), pp. 969-73. - Publication Year :
- 1991
-
Abstract
- The expression of mRNA for cripto gene, a novel transforming gene of the epidermal growth factor family, was examined in 20 alimentary tract carcinoma cell lines, 60 surgically resected tumor tissues and their adjacent normal mucosas. Although the cripto mRNA was not detected in esophageal carcinomas or in normal mucosas, it was detected in gastric and colorectal carcinomas. In gastric carcinomas, 2.2 kb cripto mRNA was detected in one cell line, all the gastric carcinoma tissues and their adjacent normal mucosas. Of 23 gastric tumor tissues 8 (34.8%) exhibited a higher mRNA level than normal gastric mucosas. cripto mRNA was detected in 2 out of 6 colorectal carcinoma cell lines. Interestingly, 18 (81.8%) out of 22 colorectal carcinoma specimens expressed a higher level of cripto mRNA than that in normal mucosas. The level of the expression was higher than that in gastric carcinoma tissues. The expression was also correlated to tumor stage of colorectal carcinomas.
- Subjects :
- Adult
Aged
Aged, 80 and over
Colorectal Neoplasms genetics
Esophageal Neoplasms genetics
Female
Gastric Mucosa physiology
Gene Expression
Humans
Intestinal Mucosa physiology
Male
Middle Aged
RNA, Messenger genetics
Stomach Neoplasms genetics
Epidermal Growth Factor genetics
Gastrointestinal Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0910-5050
- Volume :
- 82
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Japanese journal of cancer research : Gann
- Publication Type :
- Academic Journal
- Accession number :
- 1938601
- Full Text :
- https://doi.org/10.1111/j.1349-7006.1991.tb01929.x