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Trazodone generates m-CPP: in 2008 risks from m-CPP might outweigh benefits of trazodone.
- Source :
-
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry [World J Biol Psychiatry] 2009; Vol. 10 (4 Pt 2), pp. 682-5. - Publication Year :
- 2009
-
Abstract
- Since deleterious effects of m-CPP, the primary catabolic metabolite of trazodone, were last reviewed 2 years ago, research data continue to accrue showing that clinically significant levels of m-CPP (a) are generated in patients using trazodone for sleep and (b) are present 24 h a day and (c) have potentially serious ill effects. This commentary argues that the documented potential for harm and multiple risks of m-CPP outweigh potential benefits of trazodone, given the development and marketing of many safer alternatives since trazodone's introduction in the 1980s.
- Subjects :
- Animals
Antidepressive Agents, Second-Generation pharmacokinetics
Antidepressive Agents, Second-Generation therapeutic use
Anxiety chemically induced
Anxiety physiopathology
Biotransformation
Brain drug effects
Brain physiopathology
Dose-Response Relationship, Drug
Drug-Related Side Effects and Adverse Reactions
Humans
Mice
Panic drug effects
Panic physiology
Piperazines adverse effects
Receptor, Serotonin, 5-HT2B drug effects
Receptor, Serotonin, 5-HT2B physiology
Receptor, Serotonin, 5-HT2C drug effects
Receptor, Serotonin, 5-HT2C physiology
Risk Factors
Serotonin Receptor Agonists adverse effects
Structure-Activity Relationship
Trazodone pharmacokinetics
Trazodone therapeutic use
Antidepressive Agents, Second-Generation adverse effects
Piperazines blood
Serotonin Receptor Agonists blood
Trazodone adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1814-1412
- Volume :
- 10
- Issue :
- 4 Pt 2
- Database :
- MEDLINE
- Journal :
- The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 19384678
- Full Text :
- https://doi.org/10.1080/15622970902836022