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Cost-effectiveness analysis of solifenacin flexible dosing in patients with overactive bladder symptoms in four Nordic countries.
- Source :
-
Acta obstetricia et gynecologica Scandinavica [Acta Obstet Gynecol Scand] 2009; Vol. 88 (6), pp. 693-9. - Publication Year :
- 2009
-
Abstract
- Objective: The purpose of the present analysis was to analyze and compare the cost-effectiveness of solifenacin flexible dosing (5-10 mg) with tolterodine 4 mg sustained release (SR) or placebo (assumed to be comparable to no treatment) for patients with overactive bladder (OAB) symptoms.<br />Design: A decision-analytic model was constructed.<br />Methods: Costs and effects were evaluated for the three treatment options in a one-year timeframe. Costs included were treatment costs, cost of pad use, and patients productivity loss based on data from the Nordic countries.<br />Sample: Results from two randomized controlled trials were used as input data in the cost-effectiveness analysis.<br />Main Outcome Measures: Quality adjusted life years and incremental cost-effectiveness ratio.<br />Results: Solifenacin flexible dosing was more effective with respect to reducing OAB symptoms compared to both placebo and tolterodine 4 mg. Treatment with both solifenacin and tolterodine was more costly compared to placebo, but treatment with solifenacin was a less costly alternative compared to tolterodine 4 mg SR. Sensitivity analyses revealed that the conclusions were robust.<br />Conclusion: Solifenacin flexible dosing was a cost-effective treatment alternative compared to tolterodine 4 mg SR.
- Subjects :
- Benzhydryl Compounds administration & dosage
Cost-Benefit Analysis
Cresols administration & dosage
Decision Support Techniques
Female
Finland
Humans
Muscarinic Antagonists economics
Phenylpropanolamine administration & dosage
Quinuclidines economics
Randomized Controlled Trials as Topic
Scandinavian and Nordic Countries
Solifenacin Succinate
Tetrahydroisoquinolines economics
Tolterodine Tartrate
Muscarinic Antagonists administration & dosage
Quinuclidines administration & dosage
Tetrahydroisoquinolines administration & dosage
Urinary Bladder, Overactive drug therapy
Urinary Bladder, Overactive economics
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0412
- Volume :
- 88
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Acta obstetricia et gynecologica Scandinavica
- Publication Type :
- Academic Journal
- Accession number :
- 19384673
- Full Text :
- https://doi.org/10.1080/00016340902849738