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Acute hyperinsulinemia decreases plasma osteoprotegerin with diminished effect in type 2 diabetes and obesity.
- Source :
-
European journal of endocrinology [Eur J Endocrinol] 2009 Jul; Vol. 161 (1), pp. 95-101. Date of Electronic Publication: 2009 Apr 20. - Publication Year :
- 2009
-
Abstract
- Objective: Osteoprotegerin (OPG) is a soluble tumour necrosis factor-receptor-like molecule present in connective tissues, especially bone and vasculature. It is known to accumulate in the arterial wall in diabetes. As its synthesis in vascular cells is decreased by insulin, we wanted to elucidate the acute effects of insulin on plasma OPG concentrations in individuals with type 2 diabetes and obese individuals compared with lean controls.<br />Design: The study population consisted of ten type 2 diabetic, ten obese subjects, and ten lean subjects with no family history of diabetes.<br />Methods: All subjects underwent a 4-h euglycemic-hyperinsulinemic clamp. Plasma OPG, insulin, lactate, HbA1c, cholesterol, triglycerides, free fatty acids (FFA), and glucose disposal rate were measured before and at the end of the clamp.<br />Results: Baseline OPG concentrations did not differ significantly between groups. Insulin infusion decreased plasma OPG concentrations in all groups (P<0.01); however, the fall in OPG was 50% less in obese and type 2 diabetic individuals (P=0.007). Baseline OPG correlated with fasting insulin, baseline lactate, and low density lipoprotein cholesterol in the diabetic group, and with baseline FFA in the lean group. The relative change of OPG in response to insulin correlated inversely with HbA1c and baseline FFA in the lean group.<br />Conclusions: Acute hyperinsulinemia decreases plasma OPG, but with diminished effect in individuals with type 2 diabetes and obesity. Increased levels of OPG in arteries and plasma in diabetes together with the capability of plasma OPG as a cardiovascular risk predictor may be related to the described effects of insulin.
- Subjects :
- Acute Disease
Body Weight
Cardiovascular Diseases epidemiology
Cardiovascular Diseases metabolism
Diabetes Mellitus, Type 2 epidemiology
Female
Glucose Clamp Technique
Humans
Hyperinsulinism epidemiology
Insulin blood
Male
Middle Aged
Obesity epidemiology
Risk Factors
Diabetes Mellitus, Type 2 metabolism
Hyperinsulinism metabolism
Obesity metabolism
Osteoprotegerin blood
Subjects
Details
- Language :
- English
- ISSN :
- 1479-683X
- Volume :
- 161
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- European journal of endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 19380455
- Full Text :
- https://doi.org/10.1530/EJE-09-0141