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The effect of weight loss on anti-Müllerian hormone levels in overweight and obese women with polycystic ovary syndrome and reproductive impairment.
- Source :
-
Human reproduction (Oxford, England) [Hum Reprod] 2009 Aug; Vol. 24 (8), pp. 1976-81. Date of Electronic Publication: 2009 Apr 20. - Publication Year :
- 2009
-
Abstract
- Background: Anti-Müllerian hormone (AMH) has been proposed as a clinical predictor of improvements in reproductive function following weight loss in overweight and obese women with polycystic ovary syndrome (PCOS). This study aimed to assess whether baseline and/or change in AMH levels with weight loss predict improvements in reproductive function in overweight and obese women with PCOS.<br />Methods: Fifty-two overweight and obese women with PCOS and reproductive impairment (age 29.8 +/- 0.8 years, BMI 36.5 +/- 0.7 kg/m(2)) followed a 20-week weight loss programme. AMH, weight, menstrual cyclicity and ovulatory function were assessed at baseline and post-intervention.<br />Results: Participants who responded with improvements in reproductive function (n = 26) had lower baseline AMH levels (23.5 +/- 3.7 versus 32.5 +/- 2.9 pmol/l; P = 0.03) and experienced greater weight loss (-11.7 +/- 1.2 versus -6.4 +/- 0.9 kg; P = 0.001) compared with those who did not respond (n = 26). Logistic regression analysis showed that weight loss and baseline AMH were independently related to improvements in reproductive function (P = 0.002 and P = 0.013, respectively). AMH levels did not change with weight loss in both responders and non-responders.<br />Conclusions: In overweight and obese women with PCOS and reproductive dysfunction, a 20-week weight loss intervention resulted in improvements in reproductive function but no change in AMH levels.<br />Clinical Trials Registration Number: ACTRN12606000198527.
- Subjects :
- Female
Humans
Menstrual Cycle
Menstruation Disturbances therapy
Obesity blood
Obesity therapy
Polycystic Ovary Syndrome blood
Polycystic Ovary Syndrome therapy
Anti-Mullerian Hormone blood
Menstruation Disturbances blood
Obesity physiopathology
Polycystic Ovary Syndrome physiopathology
Weight Loss
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2350
- Volume :
- 24
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Human reproduction (Oxford, England)
- Publication Type :
- Academic Journal
- Accession number :
- 19380385
- Full Text :
- https://doi.org/10.1093/humrep/dep101