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Antagonistic interplay between ThPOK and Runx in lineage choice of thymocytes.
- Source :
-
Blood cells, molecules & diseases [Blood Cells Mol Dis] 2009 Jul-Aug; Vol. 43 (1), pp. 27-9. Date of Electronic Publication: 2009 Apr 16. - Publication Year :
- 2009
-
Abstract
- Differentiation of CD4(+)CD8(+) double-positive (DP) thymocytes into either CD4(+)-helper or CD8(+)-cytotoxic lineages involves several phases. It has been suggested that, following initial specification to one of the lineages by a set of lineage-specific genes during positive selection, stable cell identity is established during the commitment process by eliminating differentiation potential toward the other lineage. While the Runx3 transcription factor fixes the Cd4 gene into a silenced state during cytotoxic-lineage cell differentiation, the ThPOK transcription factor is both necessary and sufficient to generate a CD4(+)CD8(-) phenotype in post-selection thymocytes, regardless of the MHC specificity of the TCRs. Recent studies have revealed that a reciprocal antagonistic interplay between Runx3 and ThPOK is a central component in the transcription factor network governing the helper versus cytotoxic-lineage decision.
- Subjects :
- Animals
CD4-Positive T-Lymphocytes cytology
CD8-Positive T-Lymphocytes cytology
Cell Differentiation
Core Binding Factor alpha Subunits antagonists & inhibitors
Core Binding Factor alpha Subunits genetics
DNA-Binding Proteins antagonists & inhibitors
DNA-Binding Proteins genetics
Gene Expression Regulation
Mice
Transcription Factors antagonists & inhibitors
CD4-Positive T-Lymphocytes immunology
CD8-Positive T-Lymphocytes immunology
Core Binding Factor alpha Subunits metabolism
DNA-Binding Proteins metabolism
Thymus Gland cytology
Transcription Factors genetics
Transcription Factors metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1096-0961
- Volume :
- 43
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Blood cells, molecules & diseases
- Publication Type :
- Academic Journal
- Accession number :
- 19375362
- Full Text :
- https://doi.org/10.1016/j.bcmd.2009.03.004