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Effects of oxytocin on methamphetamine-induced conditioned place preference and the possible role of glutamatergic neurotransmission in the medial prefrontal cortex of mice in reinstatement.
- Source :
-
Neuropharmacology [Neuropharmacology] 2009 Apr; Vol. 56 (5), pp. 856-65. Date of Electronic Publication: 2009 Jan 21. - Publication Year :
- 2009
-
Abstract
- Accumulating evidence has shown the neuroactive properties of oxytocin (OT), a neurohypophyseal neuropeptide, and its ability to reduce the abuse potential of drugs. The present study investigated the effects of OT on the conditioned place preference (CPP) induced by methamphetamine (MAP, 2.0 mg/kg, i.p.) in mice and the possible role of glutamatergic neurotransmission in the reinstatement of CPP. The results showed that OT (0.1, 0.5, 2.5 microg, i.c.v.) significantly inhibited the acquisition and facilitated the extinction of MAP-induced CPP and abolished the reinstatement of CPP induced by restraint stress. This effect of OT could be attenuated by atosiban (Ato, 2.0 microg, i.c.v.), a selective OT-receptor antagonist. OT failed to block the expression and the reinstatement of CPP induced by MAP challenge. Extracellular glutamate (Glu) levels in the medial prefrontal cortex (mPFC) were determined using microdialysis coupled to a high-performance liquid chromatography (HPLC) with a fluorescence detection system. The results indicated that OT markedly inhibited extracellular Glu levels induced by restraint stress in CPP mice, but not those induced by MAP priming. Ato also attenuated the effects of OT on the changes in Glu levels. Therefore, these findings suggest that OT inhibits drug reward-related behaviors induced by MAP via the OT receptor, and OT blocks the reinstatement of CPP, at least partially, by interfering with the glutamatergic system in the mPFC.
- Subjects :
- Amphetamine-Related Disorders psychology
Animals
Male
Mice
Microdialysis
Prefrontal Cortex metabolism
Restraint, Physical
Reward
Stress, Psychological metabolism
Stress, Psychological physiopathology
Amphetamine-Related Disorders physiopathology
Conditioning, Psychological drug effects
Glutamic Acid physiology
Methamphetamine pharmacology
Motor Activity drug effects
Narcotics pharmacology
Neurotransmitter Agents physiology
Oxytocin pharmacology
Prefrontal Cortex drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1873-7064
- Volume :
- 56
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Neuropharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 19371575
- Full Text :
- https://doi.org/10.1016/j.neuropharm.2009.01.010