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Discovering protein kinase C active plants growing in Finland utilizing automated bioassay combined to LC/MS.
- Source :
-
Natural product communications [Nat Prod Commun] 2009 Jan; Vol. 4 (1), pp. 139-42. - Publication Year :
- 2009
-
Abstract
- Protein kinase C (PKC) modulating activity of 81 plant extracts of Finnish origin was investigated with an automated bioassay method combined to LC/MS. Twenty-one extracts from different parts of the plants inhibited PKC significantly. Fractionation of the active extract of Filipendula ulmaria showed that this method was able to identify a PKC inhibiting compound from the extract as quercetin. Our results indicate that this method is suitable for PKC screening of complex matrices and provides a quick and low volume, non-radioactive, alternative method for PKC experiments.
Details
- Language :
- English
- ISSN :
- 1934-578X
- Volume :
- 4
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Natural product communications
- Publication Type :
- Academic Journal
- Accession number :
- 19370892